Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Ethanol and Cycloserine

supplement:

Ethanol

Research Papers that Mention the Interaction

These results are somewhat consistent with previous findings suggesting that d-cycloserine administration increases cocaine craving, although they differ from other findings showing that d-cycloserine administration reduces alcohol or nicotine cravings.
Experimental and clinical psychopharmacology  •  2019  |  View Paper
However, it remains unclear whether DCS would also accelerate extinction of cue-elicited craving for alcohol.
These findings provide evidence that DCS enhances extinction of cue-elicited craving for alcohol in individuals with AUDs in the context of outpatient treatment.
Translational Psychiatry  •  2015  |  View Paper
Conclusions: The results suggest that DCS may temporarily augment cue-elicited craving for alcohol.
Results: Individuals who received DCS showed increased craving to alcohol cues as compared with individuals who received placebo during the first test session.
The American journal of drug and alcohol abuse  •  2012  |  View Paper
These results may suggest that decreased numbers of DCs may be responsible for reduced adaptive immune responses and increased susceptibility to infections and cancer development observed in patients exposed to alcohol.
Human & experimental toxicology  •  2012  |  View Paper
However, the combination of ethanol and DCS produced significantly greater impairment than both ethanol or DCS administered alone on a test of verbal fluency and aspects of memory function.
Alcoholism, clinical and experimental research  •  2008  |  View Paper
The enhanced sensitivity to the facilitatory effect of DCS in ETOH withdrawn animals may be mediated by adaptive changes in N-methyl-D-aspartate (NMDA) receptor provoked by ETOH dependence.
Neuroscience  •  2006  |  View Paper
Furthermore, the similarity between the blockade by DCS of anxiolysis induced either by ethanol or by HA-966 strengthens the suggestion that ethanol acts on the glycine site of the NMDA receptor complex.
The … that DCS , at doses that did not affect the behavior of control animals, significantly (p < 0.05) prevented the increase in the … of open-arm entries and the time spent in the open arms of elevated plus-maze test induced by ethanol , exhibiting a U-… dose-response curve.
Alcoholism, clinical and experimental research  •  1997  |  View Paper
In the present study we examined if compounds that act as agonists at the NMDA receptor complex, D-cycloserine (a partial agonist at the glycine positive modulatory site) and N-methyl-D-aspartate (an agonist at the glutamate binding site), could antagonize the discriminative stimulus effects of ethanol.
Alcohol  •  1997  |  View Paper
In a recent study, we showed that D-cycloserine , an agonist at the glycine site of the NMDA receptor, enhances the development of rapid tolerance to ethanol.
In the present study, we report that the acquisition of rapid tolerance to the motor incoordination effect of ethanol (tilt-plane test) was increased only when D-cycloserine was injected before, but not after, the intoxicated practice under ethanol.
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper
In the present article, we show that D-cycloserine (CS), an agonist at the glycine site of the NMDA receptor that enhances learning and memory, also enhances the development of rapid tolerance to ethanol.
Pharmacology Biochemistry and Behavior  •  1993  |  View Paper
Show More