Possible Interaction: Ethanol and Curcumin

“Mice treated with ethanol and curcumin significantly (P < 0.05) showed a lower hepatic PC-OOH level compared to mice treated with only ethanol.”

“ Curcumin attenuates liver injury induced by ethanol , thioacetamide, iron overdose, cholestasis and acute, subchronic and chronic carbon tetrachloride (CCl4) intoxication; moreover, it reverses CCl4 cirrhosis to some extent.”

“According to … findings, ethanol triggered reactive oxygen species (ROS), apoptosis, neuroinflammation, and memory …, which were significantly inhibited with the administration of curcumin , as assessed by ROS, lipid peroxidation (LPO), and Nrf2/HO-1 (nuclear factor erythroid 2-related factor 2/Heme-oxygenase-1) expression in the experimental mice brains.”

“Finally, the expression of synaptic proteins and the behavioral results also supported the hypothesis that curcumin may inhibit memory dysfunction and behavioral alterations associated with ethanol intoxication.”

“In conclusion, Binge ethanol drinking causes spatial memory deficiency by reduction of BDNF, and the combination of curcumin and swimming training improves impaired spatial memory after binge ethanol drinking.”

“Coordinated pathway alteration in ethanol groupEthanol‐induced fatty acid biosynthesis was suppressed by curcumin.”

“Glyoxylate and dicarboxylate metabolism and pyruvate metabolism were inhibited in mice fed ethanol diet plus curcumin.”

“When the EtoH +300 mg kg−1 ATZ-animals were pretreated with curcumin (an antioxidant), the histopathological changes and peroxidative damages in both tissues were blocked.”

“In addition, curcumin also corrected the high level of histone H3K9 acetylation induced by alcohol.”

“In vitro experiments demonstrated that curcumin treatment could reverse the up-regulation of active forms of caspase-3 and caspase-8, and down-regulation of bcl-2 induced by alcohol treatment.”

“Further, activated Nrf2 by curcumin inhibited p53 expression in both livers and cultured hepatocytes under alcohol stimulation.”

“ Curcumin supplementation significantly prevented these deleterious actions of chronic ethanol and high ω-3 PUFA.”

“Furthermore, acute ethanol treatment increased the NOS activity and NO production in brain regions associated with memory including prefrontal cortex (PFC), amygdala and hippocampus, while this enhancement was suppressed by pretreatment with curcumin.”