Possible Interaction: Ethanol and Creatinine

“Administration of 20% ethanol (5 g/kg b.wt/day) for 60 days resulted in a significant rise in the plasma concentrations of urea and creatinine with decreased levels of uric acid.”

“Acute ethanol intoxication further increased serum levels of GOT, GPT, BUN, Cre , LDH, CPK, TNF-α and IL-6 elevation following HS.”

“However, a decrease in creatinine clearance, noted only in the animals treated with Cd and EtOH , shows that functional changes indicating renal insufficiency are more serious in the co-exposed group.”

“Studies of intraluminal creatinine concentration in the distal part of the sorbent segment indicated that especially when serum concentration of creatinine is over 2 mg%, ethanol greatly increases the intraluminal creatinine concentration in the intestine.”

“Also, alcohol increased creatinine clearance only in CBL mice.”

“ Ethanol , CYP or the association of both drugs augmented serum levels of creatinine and increased the levels of superoxide (O2•-) generation and thiobarbituric acid reactive substances (TBARS) in the renal cortex.”

“ Chronic ethanol consumption increased SBP, creatinine levels, O2.- and H2O2 levels, lipid peroxidation, catalase activity, Nox4, IL-6 and TNF-α levels, and MMP-9/TIMP-1 ratio.”

“ Ethanol induced a significant increase of lipid profile, the atherogenic index, creatinine , and transaminase activities.”

“ Ethanol extract at … level of creatinine (0.65 ± 0.09; P<0.001) and urea (32.86 ± 5.88; P<0.001) associated with a significant increase in …; P<0.001) and urine volume output (11.95 ± 0.79; P<0.05) as compared to the toxic control group.”