Possible Interaction: Ethanol and Corticosterone

“In Caco-2 cell monolayers, corticosterone dose-dependently potentiated ethanol and acetaldehyde-induced tight junction disruption and barrier dysfunction.”

“This effect of acute ethanol is mediated, at least in part, by inducing stress hormones (eg, corticosterone) that decrease both … Although the effect of chronic ethanol on NK function has not been determined previously, it is known that feeding rodents ethanol chronically under conditions similar … will increase plasma corticosterone ….”

“Results from these studies suggest that EtOH intoxication prior to burn injury augments corticosterone release, which in turn suppresses intestinal T cell function by inhibiting mitogen-activated protein kinase (i.e., p38 and ERK) pathway.”

“Suppression of IL-6, but not IL-12, production by EtOH was found to be mediated by corticosterone.”

“These results suggest that ETOH has some protective effect against stress-induced increases in plasma corticosterone and NEFA.”

“In the rat, the acute administration of alcohol induces dose-related increases in plasma ACTH and corticosterone levels.”

“ Ethanol increased plasma corticosterone levels, with lower corticosterone secretion in defeated mice.”

“RESULTS The combined stress exposure of prenatal et anol an d adolescent COR T pr olonged immobility times in the forced swim test (FST), and increased investigation times and numbers in the social interaction test (SIT).”

“Offspring exposed to alcohol displayed altered cardiovascular responses to stress and had reduced circulating concentrations of the stress hormone corticosterone both under basal conditions and following a stressful challenge.”

“ Ethanol drinking reduced baseline and fear recall recovery concentrations of corticosterone relative to those exposed only to water, although there was no effect of either ethanol or stress history on fear conditioning.”