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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Colchicine
Research Papers that Mention the Interaction
“Thus, colchicine specifically inhibited the potentiating action of ethanol.”
Microtubule Depolymerization Inhibits Ethanol‐Induced Enhancement of GABAA Responses in Stably Transfected Cells“When T-lymphocyte migration was stimulated by colchicine (10(-5) mol/L), incubation with ethanol (0.25% and 0.50%, vol/vol) decreased migration to 80% +/- 4% and 66% +/- 8% of control values, respectively.”
“However, an approximate 30% inhibition of hepatic microsomal ethanol oxidation was observed by colchicine at a concentration of 4 microM and more.”
Effect of colchicine on in vivo and in vitro ethanol metabolism in the rat.“Electron microscopy of the rat liver has shown that colchicine inhibited significantly the onset of hepatic fibrosis and degenerative changes in hepatocyte organells induced by hepatotoxins (alcohol alone or alcohol in combination with CCl4).”
“C lchicine a lso produced powerful inhibitory effects on the gastric secretion produced by al cohol, whether administered intravenously or intraduodenally, and by histidine-ascorbic acid combination.”
The inhibitory effects of colchicine on the gastric secretion produced by histamine and other secretagogues.
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