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Last Updated: 3 months ago

Possible Interaction: Ethanol and Codeine

supplement:

Ethanol

drug:

Codeine

Research Papers that Mention the Interaction

In conclusion ethanol co-incubation with codeine resulted in an inhibition of codeine conversion to unknown metabolites and norcodeine, and with morphine to morphine-3-glucuronide, but no inhibition in morphine production.
European Journal of Drug Metabolism and Pharmacokinetics  •  2010  |  View Paper
In the presence of ethanol the concentrations of several intermediate and end products of ethylmorphine and codeine changed markedly from the control situation.
It was concluded that all steps in the metabolism of ethylmorphine (and codeine ) leading to the end products morphine-3-glucuronide and normorphine-3-glucuronide were inhibited by ethanol , and that the glucuronidation process were the ones most affected by ethanol.
Pharmacology & toxicology  •  1997  |  View Paper
The elimination rate constant (Kel) of codeine and morphine was reduced with approximately one-third and one-fourth, respectively, in the presence of 60 mM ethanol , whereas the presence of ethanol did not alter the Kel of norcodeine significantly.
The inhibition of codeine metabolism was dose-dependent, extending from approximately 15% at 10 mM ethanol to … 50% at 100 mM. A 3-fold increase in the ratio of morphine concentration (formed from codeine ) to the amount of codeine … observed in the presence of ethanol as compared … control cells.
The Journal of pharmacology and experimental therapeutics  •  1986  |  View Paper