Possible Interaction: Ethanol and Clozapine

“Several case studies indicate that clozapine use is associated with reductions in the use of nicotine, alcohol , or illicit drugs.”

“After adjusting for diagnosis and illness chronicity, participants taking clozapine had significantly lower odds of current alcohol , cannabis and other drug use despite similar lifetime odds.”

“The concomitant intake of clozapine and alcohol may be dangerous for the clozapine-intolerant subjects.”

“They also showed that simultaneous use of substances stimulating activity of cytochrome P-450 enzymes ethyl alcohol , finlepsin, fenitrin, nicotine) and clozapine accelerates metabolism and thereby reduces clozapine concentration in blood.”

“Studies in the DD category suggest that atypical antipsychotic agents, especially clozapine , may decrease substance use in individuals with alcohol and drug (mostly cannabis) use disorders.”

“The efficacy of newer generation antipsychotics in the reduction of substance abuse among the schizophrenic population has yet to be established, but clozapine has been shown to reduce alcohol , smoking, and cocaine use.”

“However, a synergistic tendency at a dose of 15 mg/kg and a significant synergism at a dose of 30 mg/kg were observed on ascorbic acid release when clozapine was used with ethanol.”

“These results demonstrate that clozapine dose-dependently potentiates the stimulatory effect of ethanol on striatal ascorbic acid release and this effect of clozapine may not be related to its dopamine D(2) receptor antagonism.”

“Unlike haloperidol and clozapine which potentiated LRR induced by ethanol , the selective DA antagonists, tiapride and SCH 23390, had no effect.”

“They also showed that simultaneous use of substances stimulating activity of cytochrome P-450 enzymes ethyl alcohol , finlepsin, fenitrin, nicotine) and clozapine accelerates metabolism and thereby reduces clozapine concentration in blood.”