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Last Updated: 3 years ago

Possible Interaction: Ethanol and Clopidogrel

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supplement:

Ethanol

drug:

Clopidogrel

Research Papers that Mention the Interaction

“ Alcohol significantly inhibited the hydrolysis of clopidogrel (IC50 161 mM) and 2-oxo-clopidogrel (IC50 6 mM).”

Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition

Xenobiotica; the fate of foreign compounds in biological systems • 2019 | View Paper

“Indeed, there are numerous commonly prescribed drugs with significant carboxylesterase-mediated metabolism such as enalapril, lovastatin, irinotecan, clopidogrel , prasugrel, methylphenidate, meperidine, and oseltamivir that may interact with ethanol.”

The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions

Drug Metabolism and Disposition • 2010 | View Paper

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