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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In conclusion, clonidine can reduce ethanol induced kidney injury, at least in part, by stimulating imidazoline‐1 receptor signaling.”
“Results showed that, clonidine improved renal functions and reduced ethanol induced renal inflammation and fibrosis.”
Ameliorative effects of clonidine on ethanol induced kidney injury in rats: Potential role for imidazoline‐1 receptor“Our previous studies showed that chronic ethanol feeding attenuates centrally ( clonidine ) evoked and potentiates peripherally (hydralazine) evoked hypotension in female rats.”
“In conclusion, concurrent treatment with ethanol and clonidine shifts the sympathovagal balance toward parasympathetic dominance and elicits exaggerated hypotension as a result of a reduction in cardiac contractile force.”
“Significant reductions in +dP/dtmax were observed upon concurrent treatment with ethanol and clonidine , in contrast to no effect for individual treatment.”
“The mixed alpha(2A)AR and I(1)-imidazoline receptor agonist clonidine (30, 60, and 90 microg/kg) synergistically and dose-dependently enhanced behavioral impairment elicited by ethanol (1 g/kg).”
“It was found that beside clonidine , rilmenidine, an alpha2/imidazoline receptor agonist and ST-91, an alpha2B-adrenoceptor preferring agonist inhibited the mucosal lesions induced by ethanol given intracerebroventricularly (i.c.v.).”
“Our previous studies have established that ethanol , administered acutely or chronically, attenuates the hypotensive action of the centrally acting drug clonidine.”
“ Ethanol feeding significantly attenuated clonidine hypotension whereas it potentiated the associated reduction in SDMAP.”
“RESULTS Clonidine (30 microg/kg, intravenously) or rilmenidine (400, 600, or 800 microg/kg) significantly reduced RVLM NE electrochemical signal (index of neuronal activity) and mean arterial pressure; rilmenidine effects were dose-related, and ethanol (1 g/kg) counteracted these responses.”
“The hypotensive effect of clonidine was attenuated by ethanol in a concentration-related manner.”
“The 2.5-fold increase in GMVC elicited by gastric perfusion with HCl (0.15 M) plus ethanol (25%) was depressed by clonidine.”
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