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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Ethanol
drug:
Clomipramine
Research Papers that Mention the Interaction
“Nortriptyline enhanced the deleterious effect of alcohol on the ability to learn new material, whereas chlorimipramine antagonized alcohol in this respect.”
Effect of two weeks' treatment with chlorimipramine and nortriptyline, alone or in combination with alcohol, on learning and memory“It seems as if doxepin and amitriptyline but not nortriptyline or chlorimipramine , in combination with 0.5 gm/kg of alcohol , may be especially dangerous in driving.”
“Significant potentiation of ethanol excitation was seen with 500 nM clomipramine , but not at higher or lower concentrations.”
The effects of clomipramine on the excitatory action of ethanol on dopaminergic neurons of the ventral tegmental area in vitro.“Furthermore, blocking the serotonin uptake by clomipramine 5 mg X kg-1 or 10 mg X kg-1 also reduces voluntary intake of ethanol.”
“Only desipramine, 5 and 10 mg/kg, metapramine, 10 mg/kg, clomipramine , 5 and 10 mg/kg and doxepin, 10 mg/kg, were able to reduce significantly the ethanol intake.”
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