Possible Interaction: Ethanol and Clofibrate

“Voluntary alcohol consumption or clofibrate feeding significantly lengthens lifetime, which is prolonged by 42% if ethanol is combined with clofibrate.”

“Before clofibrate … intake of alcohol was 3.47 g/kg per day and increased up to … g/kg per day, i.e., by 123% within the clofibrate feeding period while the alcohol intake of controls increased from 3.… 4.88 g/kg per day, i.e., by only 27%.”

“Addition of the hypolipemic agent clofibrate to the ethanol-containing diet reduced the adverse effects of ethanol on lipid metabolism due to activation of peroxisomal and mitochondrial enzymes involved in oxidative degradation of lipids in the liver cell.”

“The possibility of preventing adverse effects of alcohol in man by clofibrate treatment is discussed.”

“In rats anaesthetized with alcohol, clofibrate pre-treatment led to an enhancement of the effect of ADH.”