Possible Interaction: Ethanol and Ciprofloxacin

“CONCLUSIONS Ciprofloxacin treatment decreased the ethanol elimination rate by 9.4%, with a concomitant decrease in intestinal aerobic and facultative anaerobic bacteria, faecal ADH activity, and acetaldehyde production.”

“RESULTS A highly significant (p=0.001) reduction in the ethanol elimination rate (EER) was detected after ciprofloxacin medication.”

“Cutaneous adverse reaction to ciprofloxacin precipitated by ingestion of alcohol in a tetraplegic patient”

“ Alcohol treatment led to very high intracolonic acetaldehyde levels (387 ± 185 μM), which were markedly decreased by concomitant ciprofloxacin treatment (21 ± 4 μM).”

“ Ciprofloxacin and ofloxacin administered repeatedly increase the influence of ethanol on duration of ethanol-induced sleep.”

“ Ciprofloxacin treatment resulted also in significantly higher blood (p < 0.005) and intracolonic (p < 0.0001) ethanol levels than in the control animals.”

“High intracolonic acetaldehyde after ethanol injection was significantly reduced by ciprofloxacin treatment.”

“In these experiments, ciprofloxacin pre-treatment prevented the inhibitory effects of the ethanol plus GABA combination.”

“ Ciprofloxacin treatment decreased ethanol elimination rate from 310+/-9 to 282+/-13 mg/kg/h (mean+/-SE; p<0.02), markedly reduced faecal aerobic flora, and also lowered faecal ADH activity from 63+/-17 to 17+/-7 nmol/min/mg faeces (p<0.05).”

“To … ethanol on … ciprofloxacin , a fluroquinolone antibiotic with gammaaminobutyric acid (GABAA), receptor antagonist properties, adult, male Sprague‐Dawley rats (n = 6‐8/group) received intraperitoneal injections of …, 50 mg/kg), or ciprofloxacin (100 mg/kg), followed 1 hour later by gastric gavage with saline or ethanol (5 g/kg).”

“We present a case of 46-year-old male who developed erythema multiforme after ingestion of alcohol , while being treated with ciprofloxacin.”