“In summary, this study reports two major findings: ARSB modulates sulfated GAG and neurocan levels in astrocytes and astrocyte‐mediated neurite outgrowth in cocultured neurons; and ethanol inhibits the activity of ARSB, increases sulfated GAG, C4S , and neurocan levels, and thereby inhibits astrocyte‐mediated neurite outgrowth.”
“… ethanol inhibited the activity of arylsulfatase B (ARSB), … sulfate groups from chondroitin‐4‐sulfate ( C4S ) and triggers the degradation of C4S, increased total sulfated glycosaminoglycans (GAGs), C4S, and neurocan core‐protein content … outgrowth in neurons cocultured with ethanol‐treated astrocytes in vitro, effects reversed by treatment with recombinant ARSB.”