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Scandinavian journal of clinical and laboratory investigation • 2006 | View Paper
“2) The long term ethanol administration tended to decrease the amounts of gastrin, secretin and cholecystokinin contained in the gastrointestinal mucosa.”
“These studies indicate that administration of ethanol results in a transient increase in pancreatic amylase output and plasma cholecystokinin (CCK) levels.”
“A number of peptides, including cholecystokinin (CCK), neurotensin, and bombesin, have been shown to interact with the CNS actions of alcohol and may play a role in alcohol withdrawal.”
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism • 1986 | View Paper
“The possibility of neuropeptide influence on ethanol intake is presented in light of new findings that cholecystokinin and bombesin inhibit ethanol consumption in the rat.”
Neuroscience & Biobehavioral Reviews • 1985 | View Paper
“…)oral ethanol may inhibit the post-prandial activation of the cholinergic neural pathway to the pancreas in healthy subjects, (ii) in … be augmented and become resistant to the inhibition by ethanol, and (iii) the ethanol-induced increase in the postprandial CCK response in CP patients … pathophysiology of this disease.”
“In summary, intoxicating concentrations of ethanol may lead to over stimulation of pancreatic acinar cells by cholecystokinin.”
“Stimulation of cells with cholecystokinin in the presence of 50 mM ethanol led to a transformation of physiological oscillations into a single transient increase in [Ca2+]c.”
“The anti‐oxidant cinnamtannin B‐1 (10 μM) or inhibition of alcohol dehydrogenase by 4‐MP (1 mM), significantly reduced Ca2+ influx evoked by cholecystokinin in the presence of ethanol.”
“We show that a non-secretory but clinically relevant alcohol concentration (20 mm) inhibited submaximal CCK (50 pm)-stimulated amylase secretion by blocking apical exocytosis and redirecting exocytosis to less efficient BPM, indeed mimicking supramaximal CCK (10 nm) stimulation.”