Possible Interaction: Ethanol and Chlorzoxazone

“Therefore, whenever xenobiotics …, such as chlorzoxazone , paracetamol (acetaminophen), halothane, enflurane, methoxyflurane, sevoflurane and many organic solvents (… taken by an individual who is also chronically consuming ethanol , the accelerated metabolism of these agents and their clinical impact (e.g. …) and toxicological impact (accumulation of active metabolites) have to be considered.”

“Those individuals with higher survey scores, i.e. those who consumed alcohol more frequently, exhibited higher rates of chlorzoxazone metabolism.”

“ Ethanol self-administration and nicotine treatment, alone and in combination, significantly increased in vivo CZN disposition compared with that in control animals.”

“ Ethanol treatment increased the liver and renal hydroxylations of chlorzoxazone and 4-nitrophenol.”

“CYP2E1 was elevated approximately 5-fold, as estimated by immunoblot analysis, and rates of p-nitrophenol and chlorzoxazone hydroxylation were elevated 3- to 4-fold in ethanol + GdCl3-treated rats.”

“Exposure of cortical glial cultures to 25 or 100 mM ethanol for 24 h caused a fourfold and sixfold increase, respectively, in the rate of CYP2E1‐dependent 6‐hydroxylation of CZN.”