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Last Updated: 5 months ago

Possible Interaction: Ethanol and Chlorpropamide

supplement:

Ethanol

Research Papers that Mention the Interaction

Many diabetics who take chlorpropamide (a sulphonylurea compound) experience facial flushing after drinking even small amounts of alcohol.
British medical journal  •  1982  |  View Paper
Diabetics treated with chlorpropamide can have an antabuse-like flushing with ingestion of alcohol , but flushing secondary to hypoglycemia per se has not been reported.
Journal of medicine  •  1987  |  View Paper
Blood acetaldehyde concentration after intake of CP and alcohol was higher in patients with CPAF than in those without CPAF (p less than 0.005), and in those with low basal erythrocyte ALDH activity than in those with high basal enzyme activity (p less than 0.05).
Diabetes research  •  1986  |  View Paper
Eight contained clear descriptions of CPAF, while one was entirely concerned with it and included measurements of blood flow in the ear which was shown to be greater in susceptible subjects after chlorpropamide and alcohol than after alcohol alone [3].
Diabetologia  •  1984  |  View Paper
In one group of subjects, facial flushing occurred in response to the administration of alcohol and chlorpropamide.
The Journal of clinical endocrinology and metabolism  •  1982  |  View Paper
The normal breakdown of ethanol to acetic acid via acetaldehyde appears to be inhibited by chlorpropamide in the flushers.
Diabetes  •  1981  |  View Paper
Alcohol almost invariably causes facial flushing in these patients when they are given chlorpropamide (chlorpropamide alcohol flush, C.P.A.F.).
The Lancet  •  1979  |  View Paper
Non-insulin-dependent diabetes is associated with facial flushing after alcohol in patients on chlorpropamide (chlorpropamide alcohol flushing, C.P.A.F.) especially when there is a family history of diabetes.
The Lancet  •  1979  |  View Paper
We conclude that facial flushing after alcohol in people taking chlorpropamide is related to non-insulin-dependent diabetes, especially when there is a strong family history of diabetes, but not to insulin-dependent diabetes.
British medical journal  •  1978  |  View Paper
Certain (arylsulfonyl)urea hypoglycemic drugs exemplified by chlorpropamide (CP) are known to interact pharmacologically with alcohol (ethanol) to elicit a chlorpropamide-alcohol flushing (CPAF) reaction that is reminiscent of the disulfiram-ethanol reaction (DER).
Journal of medicinal chemistry  •  1992  |  View Paper
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