Possible Interaction: Ethanol and Chlorpromazine

“The combined administration of CPZ and alcohol led to inaccuracy, a slowing of reactions and impaired proprioception and coordination.”

“The concurrent administration of alcohol during treatment with CPZ or sulpiride may cause some extra risk in traffic or occupational life.”

“ Chlorpromazine (2.5 mg/kg) had a greater depressant effect in animals chronically treated with ethanol , suggesting that some alterations in the functioning of noradrenergic and/or dopaminergic systems may accompany chronic ethanol treatment.”

“ Chlorpromazine administered as a single dose 18 hours after ethanol with-drawal resulted within 18 hours in a significant increase of serum AP activity in rats fed ethanol chronically but not in their pair-fed controls.”

“In a pilot study chlorpromazine CPZ ) in vitro reversed the ethanol withdrawal effect.”

“Chlorpromazine alone impaired performance, but the impairment caused by alcohol with chlorpromazine was significantly greater.”

“Patients obliged to take chlorpromazine should be warned that the use of alcohol greatly increases the dangers of operating complex machinery, including automobiles.”

“The effect of alcohol and chlorpromazine taken together significantly impaired the performance of the subjects.”

“Abstract Chlorpromazine prolongs and intensifies the action of many central nervous system depressants, such as opiates, barbiturates, alcohol , and ether 1 .”

“We have been able to show that reserpine as well as chlorpromazine potentiates the hypnotic action of hexobarbitone and ethanol ; and furthermore, that neither potentiating agent influences the rate of metabolic transformation of the hypnotics but acts presumably by increasing the sensitivity of the central nervous system.”

“Conclusions CPZ exerts an inhibitory effect on apoptosis induced by ethanol in the rat brain, intimating that it may offer a means of protecting nerve cells from apoptosis induced by exogenous stimuli.”

“ Ethanol pretreatment 1, 3 or 12 hours before antagonized the chlorpromazine-induced hyperglycaemia but did not modify the effects of other drugs.”

“The investigated psychotropic drugs did not … but given in combination with ethanol caused significant decline of … mg/kg) by 58%, chlorpromazine (6.7 mg/kg) by 59%, imipramine (2 mg/kg) by 48%, amitriptyline (4 … 49%, phenytoin (4 mg/kg) by 53%, pyridinol (0.3 mg/kg) by 58%.”