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Last Updated: 4 months ago

Possible Interaction: Ethanol and Chlormethiazole

supplement:

Ethanol

Research Papers that Mention the Interaction

Chlormethiazole administered during ethanol withdrawal may protect against such developments.
Acta psychiatrica Scandinavica. Supplementum  •  1986  |  View Paper
The results also show that when chlormethiazole (a drug exhibiting a certain degree of cross-tolerance with ethanol ) was used either as the first-line treatment for all cases or as the first-line treatment for predetermined "high risk" patients, the incidence of delirium tremens was greatly reduced.
Acta psychiatrica Scandinavica. Supplementum  •  1986  |  View Paper
Ethanol might be expected to decrease the first-pass extraction of chlormethiazole leading to higher blood levels of this high clearance sedative frequently used in the management of alcoholic patients.
European Journal of Clinical Pharmacology  •  1983  |  View Paper
CMZ abolished the effects of ethanol on LPS-stimulated NF-κB translocation and TNF-α generation in Kupffer cells.
In cultured Kupffer cells, increased CYP2E1 content and ROS production by in vitro ethanol induction were dose-dependently inhibited by CMZ.
Hepatology research : the official journal of the Japan Society of Hepatology  •  2013  |  View Paper
All of these changes induced by ethanol feeding were significantly inhibited by the one month CMZ treatment.
Hepatobiliary surgery and nutrition  •  2012  |  View Paper
Etheno-DNA adducts are generated in the liver (HepG2) cells over-expressing CYP2E1 when incubated with ethanol;and are inhibited by chlormethiazole.
Advances in experimental medicine and biology  •  2018  |  View Paper
Chlormethiazole inhibits CYP2E1 activity and thus blocks the formation of DNA adducts in cell cultures, restores retinoic acids in alcohol fed animals and inhibits chemical induced ethanol mediated hepatocarcinogenesis.
Sub-cellular biochemistry  •  2013  |  View Paper
When ethanol was given 12 hours before chlormethiazole or pentobarbital, the heart and brain noradrenaline contents were reduced.
Agents and Actions  •  2005  |  View Paper
The most toxic combination seemed to be chlormethiazole or pentobarbital with ethanol.
Agents and Actions  •  2005  |  View Paper
Furthermore, increased plasma concentrations of retinyl palmitate in rats fed with ethanol , which indicate increased mobilization of vitamin A, were partially inhibited by chlormethiazole treatment.
Alcoholism, clinical and experimental research  •  2002  |  View Paper
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