Possible Interaction: Ethanol and Chlormethiazole

“ Chlormethiazole inhibits CYP2E1 activity and thus blocks the formation of DNA adducts in cell cultures, restores retinoic acids in alcohol fed animals and inhibits chemical induced ethanol mediated hepatocarcinogenesis.”

“The antioxidant N-acetylcysteine, and CYP2E1 inhibitor chlormethiazole blunted these effects of ethanol.”

“Six hours after CMZ treatment, the levels of both CYP2E1 protein and catalytic activity were concomitantly reduced at an IC50 value of about 5 microM. Ethanol treatment of the cells caused a 2-fold induction of CYP2E1 protein levels, which was inhibited by CMZ.”

“Benzodiazepines, clomethiazole , tiagabine, vigabatrin, pregabalin, gabapentin, acamprosate, naltrexone, GHB, topiramate, ondansetron and baclofen at low dose (≤1 mg/kg, the dose range used in randomized trials in humans: 30 and 60 mg/day) have all been shown to at best reduce motivation to consume alcohol in rats.”

“ Ethanol might be expected to decrease the first-pass extraction of chlormethiazole leading to higher blood levels of this high clearance sedative frequently used in the management of alcoholic patients.”

“ Chlormethiazole administered during ethanol withdrawal may protect against such developments.”

“The results also show that when chlormethiazole (a drug exhibiting a certain degree of cross‐tolerance with ethanol ) was used either as the first‐line treatment for all cases or as the first‐line treatment for predetermind “high risk” paitents, the incidence of delirium tremens was greatly reduced.”

“It has been shown, for example, that in fatal poisonings involving dextropropoxyphene, amitriptyline, pentobarbitone or chlormethiazole , the presence of ethanol causes a decrease in the concentration of the drug at which a given proportion of fatalities”

“Presumably as a …-life of chlormethiazole is … of alcohol , which accompanied the overdose in at least six of the subjects reported, might also be expected to inhibit the metabolism … taken orally.4 The likely influence of alcohol on chlormethiazole toxicity has previously been reported in animals) and in man.'”

“Presumably as a …-life of chlormethiazole is … of alcohol , which accompanied the overdose in at least six of the subjects reported, might also be expected to inhibit the metabolism … taken orally.4 The likely influence of alcohol on chlormethiazole toxicity has previously been reported in animals) and in man.'”