Possible Interaction: Ethanol and Chloramphenicol

“ Alcohol occasionally caused nausea, vomiting, and headache if the patient was taking some cephalosporin derivatives (such as cefsulodine) or chloramphenicol.”

“When ingested with alcohol , certain drugs (e.g. cephalosporins, sulfonylurea, metronidazole, griseofulvin, chloramphenicol ), calcium cyanamide, dimethyl formamide and certain mushrooms cause a disulfiram-alcohol type reaction.”

“Rapid … chloramphenicol (50 mg kg-1) in a 40 … (400 to 600), 30 per cent ethyl alcohol , 2 per cent benzyl alcohol and 28 per cent distilled water vehicle produced a transient but … pressure and heart rate with no effect on central venous pressure in sodium pentobarbital anaesthetised dogs.”

“The induction of acetaldehyde dehydrogenase and ethanol dehydrogenase was inhibited by chloramphenicol , suggesting de novo synthesis of these enzymes.”

“For O/W emulsion bases the addition of ethyl alcohol increased the release of chloramphenicol as its concentration was increased.”

“Low aeration levels and growth in the presence of chloramphenicol have a profound effect on ethanol and polyol production.”

“The presence of chloramphenicol in the ethanol medium further increased the alcohol dehydrogenase activity of these mutants.”

“In the presence of a moderately high concentration of ethanol , the binding of chloramphenicol to ribosomes was markedly inhibited by C-A-C-C-A(Phe) or C-A-C-C-A(Ac-Phe), while sparsomycin enhanced the inhibition.”