Possible Interaction: Ethanol and Chloral Hydrate

“ Chloral hydrate ingestion in turn affects ethanol metabolism and causes peak blood ethanol concentrations to be reached earlier and to be higher than after ethanol alone.”

“3 Ethanol and barbiturates are the most common drugs to be coadministered in overdose; both are capable of potentiating the actions of chloral hydrate.”

“A synergistic relationship is illustrated with the loss of righting reflex after combinations of ethanol and chloral hydrate.”

“The inhibition of LADH by chloral hydrate appears to be non-competitive in nature with an inhibition constant (Ki) of about 2.… inhibition of LADH by trichloroethanol was competitive and the (Ki) was about 2.7 X 10(-5) M. The elimination of ethanol from the … in chloral hydrate- ….”

“ Chloral hydrate and ethanol , given together, yielded lower blood ethanol levels than when ethanol was given alone.”

“Co-administration of chloral hydrate and ethanol had an additive effect, but both chloral hydrate and trichloroethanol at subhypnotic doses significantly prolonged ethanol sleeping time.”

“About a 1.5-fold increase in the rate of reduction of chloral hydrate was observed when 40 mM ethanol was added to the liver slice incubation.”

“This confirms an earlier hypothesis that the synergistic effect of chloral hydrate and ethanol is due to their coupled redox reaction in the alcohol dehydrogenase-mediated enzymatic process.”

“The synergism between the hypnotic effects of chloral hydrate and ethanol was investigated in male mice by determination of ED5O's and use of the isobolographic method.”

“Abstract The concurrent administration of ethanol to mice markedly enhanced the depressant action of chloral hydrate.”

“The metabolism of chloral hydrate , however, was altered by ethanol.”

“ Chloral hydrate followed by ethanol also caused greater increases in skin temperatures than other treatments.”

“ Ethanol ingestion was always associated with an increase in heart rate at 0.5 and 1.0 hours; this tachycardia was enhanced by pretreatment with chloral hydrate.”