Possible Interaction: Ethanol and Charcoal

“In experimental studies, the efficacy of charcoal in preventing systemic absorption of many drugs has been of the same order or even better than that of emesis, but in certain poisonings the efficacy of charcoal is inadequate, e.g. in those caused by ethanol , methanol or iron salts.”

“The concomitant ingestion of alcohol (50 g) with drugs antagonized only slightly the ability of charcoal to reduce the absorption of aspirin and quinidine.”

“A disulfiram-like reaction can be evoked in dogs by ethanol administration as soon as one hour and as long as 24 hours after a single large dose of animal charcoal.”

“of animal charcoal resulted in a sensitivity to ethanol which persisted for as long as three weeks.”

“The ethanol concentration in the SAC group was significantly less than control only at 2.0 hours (31.6 mg/dl vs 36.6 mg/dl, p less than 0.01).”

“When ethanol was administered with charcoal and strychnine, the increase in the LD50 was only 220 fold which is significantly (p less than 0.05) less than without ethanol.”

“The rapid separation of acetyl(−)carnitine from acetyl-CoA is accomplished by the selective adsorption of the latter on charcoal in the presence of acid and ethanol.”

“We report on an extensive characterization of the cracking noise produced by charcoal samples when dampened with ethanol.”

“With increasing concentrations of ethanol , there were substantial decreases in the adsorption of ACET, PHB, and PHY to charcoal.”