Possible Interaction: Ethanol and Ceruletide

“ Ethanol sensitizes acinar and stellate cells to the PTHrP-modulating effects of cerulein.”

“In mice receiving ethanol plus cerulein , there was increased collagen deposition as compared with other treatment groups as well as increased frequency of α-smooth muscle actin and desmin-positive PSC, which also showed significantly enhanced CTGF protein production.”

“Matrix metalloproteinase 9 expression was transiently decreased in mice fed ethanol and given caerulein compared with the group given caerulein but not fed ethanol.”

“ Ethanol (35 mM) sensitized the acinar cells to the effects of caerulein (10(-10) to 10(-7) M) on zymogen activation but had no effect alone.”

“Both ethanol and FAEE induce increased intracellular trypsinogen activation by more than 50% in the presence of physiologic concentrations of cerulein in vitro.”

“These data indicate that Cae activated PLD in the presence of ethanol caused PEt production in pancreatic acini.”

“Moreover, 4-hour pre-infusion of ethanol caused a significant increase in pancreatic cathepsin B output stimulated by caerulein (0.2 microgram/kg.hr) and secretin (0.2 CU/kg.hr) compared with the control rats.”

“In the presence of ethanol, Cae also significantly stimulated above control values the formation of [3H]phosphatidylethanol.”

“Chronic feeding of the ethanol diet followed by treatment with CR resulted in increases in serum lipase content, interstitial edema, karyorrhexis, and acinar vacuolization that were significantly greater than that seen in rats fed the control diet and treated with CR.”

“It is concluded that chronic ethanol intake in the rat intensifies AP that is subsequently induced by CR.”