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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Cefoperazone
Research Papers that Mention the Interaction
“Several reports have described an unpleasant disulfiramlike reaction to alcohol experienced by patients taking cephalosporin antibiotics such as cefamandole (CMD), cefoperazone and moxalactam (1-4).”
Inactivation of aldehyde dehydrogenase by a putative metabolite of cefamandole re:K. J. Freundt et al. Infection 13 (1985) 91“A disulfiram-like reaction with alcohol has been reported up to 3 days after the last dose of cefoperazone ; thus alcohol should be avoided for at least 72 hours after the end of treatment with cefoperazone.”
“Disulfiram-like reactions are also related to the side chains associated with coagulation defects and have been reported when patients receiving cefoperazone , moxalactam, or ceftriaxone have ingested alcohol.”
“These results highlight concomitant ingestion of alcohol and cefoperazone generated disulfiram-like reaction by way of disrupting normal metabolic pathway.”
GC-MS based metabolomics of CSF and blood serum: Metabolic phenotype for a rat model of cefoperazone-induced disulfiram-like reaction.“Previously, we have reported that cefazolin and cefoperazone treatments attenuated ethanol consumption, at least in part, through upregulation of GLT-1 expression in male alcohol-preferring (P) rats.”
“We found that cefazolin and cefoperazone treatments decreased ethanol intake and upregulated both GLT-1 isoforms, GLT-1a and GLT-1b, in nucleus accumbens (NAc) and prefrontal cortex (PFC) compared to saline treated group.”
“ Cefoperazone added to the incubation medium inhibited ethanol and acetaldehyde metabolism in a concentration-dependent manner.”
“The data indicate that cefoperazone inhibits ethanol metabolism in rat liver homogenates in a concentration-dependent manner.”
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