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Last Updated: 3 years ago

Possible Interaction: Ethanol and Cefoperazone



Research Papers that Mention the Interaction

Several reports have described an unpleasant disulfiramlike reaction to alcohol experienced by patients taking cephalosporin antibiotics such as cefamandole (CMD), cefoperazone and moxalactam (1-4).
Infection  •  2005  |  View Paper
A disulfiram-like reaction with alcohol has been reported up to 3 days after the last dose of cefoperazone ; thus alcohol should be avoided for at least 72 hours after the end of treatment with cefoperazone.
Drugs  •  2012  |  View Paper
Disulfiram-like reactions are also related to the side chains associated with coagulation defects and have been reported when patients receiving cefoperazone , moxalactam, or ceftriaxone have ingested alcohol.
The American journal of medicine  •  1990  |  View Paper
These results highlight concomitant ingestion of alcohol and cefoperazone generated disulfiram-like reaction by way of disrupting normal metabolic pathway.
Biochemical and biophysical research communications  •  2017  |  View Paper
Previously, we have reported that cefazolin and cefoperazone treatments attenuated ethanol consumption, at least in part, through upregulation of GLT-1 expression in male alcohol-preferring (P) rats.
We found that cefazolin and cefoperazone treatments decreased ethanol intake and upregulated both GLT-1 isoforms, GLT-1a and GLT-1b, in nucleus accumbens (NAc) and prefrontal cortex (PFC) compared to saline treated group.
Brain Research  •  2016  |  View Paper
Cefoperazone added to the incubation medium inhibited ethanol and acetaldehyde metabolism in a concentration-dependent manner.
The data indicate that cefoperazone inhibits ethanol metabolism in rat liver homogenates in a concentration-dependent manner.
The Journal of antibiotics  •  1984  |  View Paper