Possible Interaction: Ethanol and Catechin

“ Alcohol in the ARW hastened the elimination of (+)-catechin from the plasma compartment.”

“All the agents, except catechin , tended to reduce the expression of SOD2 induced by ethanol.”

“ Catechin prevented CYP2E1 induction by ethanol.”

“Using real time RT-PCR, we found inhibition of LPS and poly I C induced TNF-α gene transcription by ethanol.”

“ Tea alcohol significantly decreased the O2−, H2O2 and HOCl amounts via catechins and not caffeine.”

“BACKGROUND Acute ethanol administration just prior to a stimulus, such as the viral mimic poly I: C , results in decreased proinflammatory cytokine production.”

“Treatment of mice with ethanol shortly before treatment with poly I: C yielded a significant increase in the corticosterone response as compared to the response to poly I:C alone, but the increase was small and not likely sufficient to account for the anti-inflammatory effects of ethanol.”

“The activity of phospholipase A and C increased significantly in the liver of groups given alcohol , thermally oxidized oil and alcohol + thermally oxidized oil when compared with the normal control rats, whereas the activity was decreased with the cumin treatment.”

“The activity of phospholipase A and C increased significantly in the liver of groups given alcohol , thermally oxidized oil and alcohol + thermally oxidized oil when compared with normal control rats, whereas the activity was decreased upon DA treatment.”

“However, poly I C significantly enhanced lytic function, and this enhancement was suppressed by EtOH (by approximately 50%).”

“Addition of ethanol (17 to 340 mM) to cultured rat hepatocytes stimulated the breakdown of phosphatidylcholine phospholipases D and C as measured by an increase in the rate of release of choline and phosphocholine into the medium.”