Possible Interaction: Ethanol and Carrageenan

“Using LPS and carrageenan air pouch models in mice, we found that physiological concentrations of ethanol (1–5 g/kg) significantly blocked leukocyte recruitment (50–90%).”

“Results The 60% and 90% ethanol elution fractions of EMS contained berberine, and both inhibited edema after carrageenan injection, with inhibitory rates of 31.04–40.86% and 48.84–52.18%, respectively, and with a significant reduction in MPO activity and NO production.”

“The ethanol extracts at 400mg/kg, showed maximum inhibition of inflammation induced by carrageenan (44%), dextran (40%), cotton pellets (37.47%).”

“The rat paw edema due to carrageenan , yeast, and dextran was dose-dependently antagonized by oral administration of ethanol.”

“ ETE showed significant inhibition of carrageenin paw oedema and granulation tissue formation in rats.”

“The carrageenin and nystatin-induced paw edemas were dose-dependently antagonized by oral administration of ethanol.”

“Moreover, upon 20 wt% ethanol addition, the average radius of gyration of κ-carrageenan strand increased from 1.18 ± 0.03 of control to 1.55 ± 0.02 nm by SAXS.”

“Administration of EtOH extract at dose 400 mg/kg/bw exhibited a maximum inhibition of inflammation induced by Carr for 3 and 5 hours compared to reference group Indomethacin (Indo).”