Possible Interaction: Ethanol and Carnitine

“Urinary acetylcarnitine content significantly increased following administration of ethanol plus carnitine , but not when L-carnitine alone was administered.”

“ TC and FC were significantly decreased in groups receiving alcohol at 4 months.”

“Several studies have shown the capacity of carnitine and its derivatives to influence ethanol metabolism.”

“Although carnitine retards ethanol oxidation in the intact animal, the in vitro activities of ethanol-metabolizing enzymes remain unaltered.”

“The carnitine supplemented diet prolonged the half-life of ethanol due to attenuation of ethanol metabolism which is similar to that reported earlier in rodents.”

“When a single dose of ethanol was given orally after 5 days of carnitine supplementation, the blood levels of ethanol remained significantly elevated for 2-8 hours in the carnitine supplemented animals.”

“ Carnitine gave some protection against increases in SGOT levels in animals receiving ethanol.”

“After ethanol administration, carnitine concentration alters in a similar way to CoA concentration.”

“The multiple possible therapeutic effects carnitine could have on ethanol metabolism and the early evidence available for carnitine supplementation as a treatment for AUD provide a foundation for future randomized control trials of carnitine for treating AUD.”