Possible Interaction: Ethanol and Cardiotonic Agents

“Thus, while the risk/benefit ratio varies for individuals, the use of alcohol for cardioprotective purposes should not be encouraged as a public health measure.”

“Other variables potentially influencing the development of CHD such as a reduced tendency for blood coagulation and increased fibrinolytic activity has been enhanced by alcohol and may be considered as possible additional mechanisms for the cardioprotective effects of the agent.”

“The existence and potential level of cardioprotection from alcohol use is contested in alcohol studies.”

“Low-to-moderate intake of alcohol can be cardioprotective.”

“Although a cardioprotective and life-prolonging effect has been shown to be associated with regular moderate use of alcohol , a global recommendation in favor of regular moderate drinking is nevertheless not justifiable at present, because of the well-known considerable risks and potential health hazard associated with drinking.”

“ CP also attenuates an enhancement of gut I/R-induced responses by chronic ethanol consumption via the reduction of blood endotoxin levels.”

“Pretreatment with CP attenuated the enhancement of gut I/R-induced responses by chronic ethanol consumption.”

“Recent studies reveal that brief ethanol exposure induces cardioprotection against simulated ischemia in cardiomyocytes by the activation of protein kinase C- epsilon.”

“BACKGROUND Consumption of moderate amounts of alcohol has been reported to exert a cardioprotective effect in individuals.”

“Our findings suggest (i) that regular ethanol consumption induces long-term cardioprotection through sustained translocation of epsilonPKC and (ii) that PKC activity is necessary at the time of ischemia to mediate ethanol's protective effect against ischemia-reperfusion injury.”