Possible Interaction: Ethanol and Carbon Monoxide

“Additionally, ethanol caused less than a 2-fold shift to the left in the dose-response function of Co 2 -6749 in the rotorod procedure in rats.”

“ Ethanol could have a neuroprotective effect on the occurrence of DNS in CO poisoning patients.”

“Our findings suggest that acute ethanol use, poorer socioeconomic position, and inadequate education status about the danger of CO are associated with an increased risk of fatal CO poisoning.”

“Conversely, the level of Co and Mn in the cord blood of offspring maternally exposed to ethanol is decreased.”

“ ECO levels are increased in the following situations: consumption of alcohol or polyol-rich sweets, lactose intolerance, haemolytic anaemia, types 1 and 2 diabetes, asthma, chronic obstructive pulmonary disease (COPD) and bronchiectasis.”

“A protective effect of low ethanol concentration was noted in persons exposed to CO.”

“A protective effect of low ethanol concentration (< 3 per thousand) was noted in persons exposed to CO.”

“ Ethanol had an effect on the … kinetic parameters that describe CO binding: it decreased the rate of CO binding, suggesting a decrease in the protein's conformational flexibility, and increased … photosensitivity, which indicates a local effect in the active site region such as strengthening of the heme-CO bond.”

“By contrast, 50-87% of the oxidation of ethanol by these cells was inhibited by carbon monoxide , metyrapone and SKF-525A, all three of which are known to inhibit various species of microsomal cytochrome P-450.”

“The influence of alcohol , narcotic drugs, and tranquilizers on carbon monoxide can be seen in some of these traumatic deaths.”