Possible Interaction: Ethanol and Captopril

“Furthermore, to obtain more accurate results for related factors of PaCa misdiagnosis, subgroup analysis must include … patients who were diagnosed with PaCa within 2 years aft er CP diagnosis (41 patients) because alcohol and smoking may exert … erent eff ects on CP to PaCa progression and initial PaCa development.”

“Combined exposure to even low doses of alcohol with THC, HU-210, or CP 55,940 caused a greater incidence of birth defects, particularly of the eyes, than did either treatment alone.”

“ Prenatal ethanol also increased peptide levels in the medial-posterior zone of the CP , and strongly augmented Met-enk content in the hippocampus and hypothalamus.”

“In addition, it was found that 1 ml/kg of a 5% alcohol solution has significant behavioural effects on its own, and reverses the effects of CP 55,940 on PPI.”

“ Captopril and enalapril reduces ethanol sleeping time.”

“Results: The acute administration of WIN 55,212-2 (0.5–2 mg/kg; IP) and CP 55,940 (3-30 µg/kg; IP) induced a significant, dose-dependent increase in ethanol intake.”

“In the first experiment, CP 55,940 (10, 30 or 50 microg/kg) caused a dose-dependent increase in break points for beer (containing 4.5% ethanol v/v) and for near-beer.”

“In the second experiment, CP 55,940 (10 or 30 microg/kg) dose-dependently increased break points in rats licking for 'light' beer (containing 2.7% ethanol v/v) or for a sucrose solution (8.6% w/v) containing the same number of calories as the beer.”

“Continuous intraventricular infusions of ANG II for 7 days or low doses of oral or SC-infused captopril for up to 12 days increased the intake of ethanol.”

“Chronic peripheral treatments with low doses of the angiotensin-converting enzyme inhibitor, captopril , enhance daily intakes of dilute ethanol solutions in rats as they do the intakes of water and saline solutions.”

“Local angiotensin II synthesis and receptor activation at the SFO appear to be the mechanism of the enhanced ethanol drinking during captopril.”

“Placing captopril into the drinking water or infusing it SC increases daily intake of 6% (v/v) ethanol from 30-100% over 4-12 days of treatment.”

“The prolonged effect of alcohol (for a period of 14 days) resulted in a decrease in oxidative processes as well as in glycolytic activity with a subsequent decline in myocardial ATP and CP levels.”