Possible Interaction: Ethanol and Capsaicin

“The decrease of GTPD evoked by ethanol was inhibited by the capsaicin application, which was reproducible.”

“Experimental injury in the rat stomach induced by pyloric ligation or injurious factors, such as hydrochloric acid, taurocholate, aspirin, and ethanol , is reduced by stimulation of extrinsic afferent nerve terminals by intragastric administration of capsaicin prior to …”

“Calcium responses elicited by the TRPV1 agonist capsaicin were potentiated by treatment with ethanol , but morphine was not able to inhibit ethanol‐sensitised capsaicin responses.”

“Background: A low dose of capsaicin and its natural homologs and analogs (capsaicinoids) have shown to prevent development of gastric mucosal damage of alcohol and non-steroid anti-inflammatory drugs.”

“We found that fetal ethanol exposure attenuated the oral aversiveness of ethanol and capsaicin , but not mustard oil, in adolescent rats.”

“These two ethanol behaviors were changed in the opposite direction after injection of capsaicin , a selective TRPV1 agonist, in wild type mice.”

“However, the concurrent administration of capsaicin (1 x 10(-8) microg/ml or 1 x 10(-7) microg/ml) and ethanol significantly ameliorated most of the morphological scores excepting yolk sac circulation and hindlimb scores (p<0.05).”

“Whereas, TRPV1 agonists, capsaicin and piperine, inhibited gastric lesions induced by ethanol , 1% ammonia, and aspirin, but had less of an effect on 0.6 M HCl-induced gastric lesions.”

“In the presence of neurotoxic doses of capsaicin, the negative influence of capsaicin on restraint, ethanol , or indomethacin lesions consistently affected salutary activity of BPC 157.”

“ EtOH caused a Ca2+-dependent release of neuropeptides from guinea pigs airways, an effect that was inhibited by both capsaicin pretreatment and the TRPV1 antagonist capsazepine (CPZ).”