Possible Interaction: Ethanol and Calcium Supplement

“ResultsIn addition to previously reported effects on the extracellular matrix and the promotion of a pro-inflammatory environment, we found that CBA adversely affects gene regulatory networks that involve “universal” cellular functions, protein homeostasis, calcium and ion homeostasis, neuronal growth and signaling, and satellite cell growth and survival.”

“D-Glyceric acid (D-GA) calcium has been reported to accelerate ethanol oxidation in vivo in rats (Eriksson et al., Metabolism, 56, 895-898 (2007)).”

“Studies have implicated Ca++ in the actions of ethanol at many biochemical levels.”

“In keratinocytes, EtOH had no effects on mitogenesis after shorter (17-hr) treatments, but it partially prevented inhibition of DNA synthesis elicited by longer treatments (3-4 days) with 2 mM calcium (Ca2+), a differentiation-inducing agent.”

“Acute exposure to ethanol (25–100 mM) inhibited the NMDA‐mediated increase in intracellular calcium in a dose‐dependent manner without affecting basal calcium concentrations.”

“It is proposed that the acute intoxicational effects of ethanol result, in large part, from a diminished ability to elevate intraneuronal calcium ion concentrations via specific receptor-gated and voltage-gated mechanisms.”

“In vitro addition of ethanol , propanol or butanol increased calcium-dependent 86 Rb efflux of human RBC at low concentrations of free calcium , but did not change the calcium-independent efflux of 86 Rb.”

“The prolonged feeding of ethanol to rats alters in vitro mitochondrial transport of calcium.”

“Exposure to ethanol or pentobarbital in vitro stimulated the ATP-dependent efflux of calcium from human red blood cells (RBC) and the Ca2+-ATPase activity of RBC and rat brain synaptic plasma membranes (SPM).”

“Based on the data derived from this investigation it appears that calcium ions may have a limited role, if any, in the central actions of ethanol when steady-state calcium ion concentrations are considered.”