Possible Interaction: Ethanol and Calcium Channel Blockers

“Recently, it is demonstrated that L-, N- and T-type calcium channel blockers attenuate the acute locomotor stimulant effects of ethanol.”

“The calcium channel blocker , diltiazem and the chelating agent, BAPTA, reduced the activation of MAPK activity by ethanol , significantly.”

“The dihydropyridine calcium channel antagonist , nimodipine, was found to decrease the extent of tolerance that developed to the ataxic action of ethanol in experimental designs in which the tolerance was not context-specific, when ethanol was given by liquid diet.”

“Second, conformational changes brought about by ethanol at voltage-dependent calcium channels in the brain may antagonize the inhibitory effect of the dihydropyridine calcium antagonist , producing the reversal of convulsions.”

“Chronic administration of the calcium channel antagonist , isradipine (PN-200-110) during ethanol treatment significantly decreased the withdrawal syndrome, both in vivo and in vitro.”

“These results extend the class of calcium channel blockers capable of producing a behavioral interaction with ethanol.”

“2 The (+)‐isomer of the calcium channel antagonist PN 200–110 (isradipine) significantly decreased all the recorded signs of hyperexcitability in the slices during ethanol withdrawal.”

“Maintaining bovine adrenal chromaffin cells for several days in culture medium, containing inhibitory concentrations of ethanol alprazolam or buspirone, produced a marked increase in binding sites for a [3H]dihydropyridine [DHP] calcium channel antagonist , on cell membranes.”

“Treatment of rats with calcium channel blockers before ethanol or indomethacin administration resulted in a significant decline in the mean number of lesions per glandular stomach, the damaged area of the glandular stomach, and the severity of lesions.”