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Possible Interaction: Ethanol and Calcium Carbimide

supplement:

Ethanol

Research Papers that Mention the Interaction

The most commonly prescribed agents are the aversive drugs (e.g., disulfiram, calcium carbimide ), which when ingested prior to alcohol produce an unpleasant physiologic reaction, which is supposed to deter further drinking.
Addictive behaviors  •  1981  |  View Paper
In a double‐blind, placebo‐controlled study involving five … alcoholic volunteers, oral administration of 0.7 mglkg of calcium carbimide (CC) 12 hr … ingestion of ethanol (0.125, 0.25, and 0.5 gm/kg) produced an interaction … of increased blood acetaldehyde level, tachycardia, and decreased diastolic blood pressure.
Pretreatment with CC reduced the rate of ethanol metabolism at the 0.5 gm/kg ethanol dose.
Clinical pharmacology and therapeutics  •  1979  |  View Paper
Calcium carbimide pretreatment at the 4-h interval produced increased blood ethanol level for the last hour of the interaction and reduced the rate of ethanol metabolism.
For these experimental conditions, calcium carbimide had a duration of action of at least 24 h to produce an interaction with ethanol.
SummaryIn six male alcoholic volunteers, oral administration of calcium carbimide (0.7 mg/kg) before ingestion of ethanol (0.5 g/kg) produced an interaction consisting of increased blood acetaldehyde level, tachycardia and increased pulse pressure, which was due mainly to decreased diastolic blood pressure.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
In the second part of this study seven subjects received 50 mg of calcium cyanamide 4 hr prior to an intravenous ethanol dose of 0.2 g/kg.
Pharmacology & toxicology  •  1992  |  View Paper
Ingestion of calcium carbimide caused significant elevations in blood acetaldehyde (p less than 0.001) and ethanol (p less than 0.05) levels, but acetaldehyde did not influence platelet aggregability or the aggregation-associated TXB2 formation.
Journal of toxicology. Clinical toxicology  •  1987  |  View Paper
Ingestion of calcium carbimide caused a significant elevation in blood acetaldehyde (p less than 0.001) and ethanol (p less than 0.05) levels, but acetaldehyde did not influence platelet aggregation or TXB2 formation.
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement  •  1987  |  View Paper
When ingested with alcohol , certain drugs (e.g. cephalosporins, sulfonylurea, metronidazole, griseofulvin, chloramphenicol), calcium cyanamide , dimethyl formamide and certain mushrooms cause a disulfiram-alcohol type reaction.
Schweizerische medizinische Wochenschrift  •  1982  |  View Paper
In 1953, Fergusen 4 reported that citrated calcium carbimide (Temposil) in the presence of ingested alcohol produced an acetaldehyde reaction similar to that of disulfiram and alcohol.
Journal of the American Medical Association  •  1958  |  View Paper
Combined ethanol and calcium carbimide treatment for 2, 5 or 8 days (E + CC) markedly increased blood acetaldehyde levels.
Alcohol and alcoholism  •  2002  |  View Paper
Combined ethanol and calcium carbimide treatment increased blood-acetaldehyde levels and ANP mRNA levels by 40-60% in 2-8 day experiments, compared to the controls.
Alcohol and alcoholism  •  2000  |  View Paper
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