Possible Interaction: Ethanol and Calcitonin Gene-Related Peptide

“Interestingly, there were significant increases in CGRP levels after exposure to vehicle ( ethanol ) as well as capsaicin, although this did not induce relaxant responses.”

“Exposure of ethanol after 1 mol/L NaCl increased intragastric CGRP levels from 166 +/- 27 to 713 +/- 55 pg/2 min (n = 4, P < 0.05), and the protective action of 1 mol/L NaCl was inhibited by indomethacin treatment.”

“These findings suggest that 96% ethanol induced a decrease of CGRP-li deriving from a capsaicin-sensitive pool and that CGRP may play a role in gastric ulcer pathogenesis of haemorrhagic lesions induced by concentrated ethanol.”

“The presence of circulating antibodies to calcitonin gene‐related peptide (CGRP) enhanced the damaging effect of ethanol on the rat gastric mucosa.”

“Close arterial infusion of CGRP (15 pmol/min) to the stomach, via a catheter placed in the abdominal aorta proximal to the celiac artery, significantly reduced gross mucosal damage caused by ethanol and aspirin whereas mean arterial blood pressure (BP) was not altered.”

“Prolonged (30 consecutive days), voluntary alcohol intake under the homecage 2-bottle alcohol vs. water” regimen strongly increased CGRP intensity in BNST of sP rats in a subnucleus-specific manner: in BNST-AL, BNST-AVm, and BNST-AM.”