Possible Interaction: Ethanol and Caffeine

“This study shows that reduced intentional control under alcohol can be counteracted by caffeine or an environmental incentive.”

“Memory and motor function were shown to be facilitated by nicotine or caffeine , and the debilitating effects of alcohol were frequently antagonised by either drug.”

“Results showed that a history of combined alcohol and caffeine administrations increased alcohol tolerance compared with an exposure history to either drug alone.”

“ Caffeine has been shown to reverse some of the performance-impairing effects of ethanol.”

“Thus, caffeine , similar to other stimulants, can reverse the physiologically sedating effects of ethanol , although other negative effects remain.”

“ Caffeine 8 mg/kg plus ethanol 0.4 g/kg produces target caffeine and ethanol levels of 8 to 10 &mgr;g/mL and 30 to 50 mg/dL, respectively.”

“Some groups were led to expect that caffeine would counteract the impairing effect of alcohol and others were led to expect no counteracting effect.”

“The present study examined whether concurrent consumption of caffeine may differentially affect these aspects of alcohol and performance.”

“Studies in rats with ethanol or nicotine reveal only an additive effect with caffeine.”

“However, caffeine potentiates the teratogenic effect of other substances, such as tobacco, alcohol , and acts synergistically with ergotamine and propranolol to induce materno-fetal vasoconstrictions leading to malformations induced by ischemia.”

“Therefore, even though caffeine does not seem to be harmful to the human fetus when intake is moderate and spread out over the day, some associations, especially with alcohol , tobacco, and vasoconstrictive or anti-migraine medications should be avoided.”

“Further studies in females showed that ethanol completely obliterated the well documented stimulation of the phosphatase by caffeine ; however, it did not alter the caffeine effect in males.”