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Last Updated: 5 years ago
supplement:
Ethanol
Research Papers that Mention the Interaction
“Pretreatment of 100 mM ethanol treated VL-17A cells with 0.4 mM buthionine sulfoximine ( BSO ) or 1 mM diethyl maleate (DEM) had opposite effects.”
The effects of changes in glutathione levels through exogenous agents on intracellular cysteine content and protein adduct formation in chronic alcohol-treated VL17A cells“The cytotoxicity of APAP or BSO to HLE/2E1 cells was inhibited by the addition of ethanol or vitamin E. However, the cytotoxicity of both APAP and BSO was enhanced by 24-h preincubation of HLE/2E1 cells with ethanol.”
“This effect was exacerbated in mice given ethanol with 7.6 mM BSO , causing a 72% decline in hepatic glutathione.”
“While ethanol alone caused no decrease in mitochondrial glutathione, inclusion of 7.6 mM BSO caused a 2-fold decline compared with untreated controls.”
L-Buthionine (S,R) sulfoximine depletes hepatic glutathione but protects against ethanol-induced liver injury.“ ET increased H(2)O(2) or O(2*-) only in the presence of BSO or DEM.”
“Combined treatment with BSO plus EtOH further decreased mitochondrial GSH up to 70% in comparison to control.”
“The combined treatment of EtOH plus BSO induced a further mitochondrial GSH decrease up to 70% with respect to control.”
“The NMDA antagonists 2-amino-5-phosphonovaleric acid (APV), MK-801 and an inhibitor of glutamate synthesis, methionine sulfoximine , increased sensitivity to ethanol in both lines of mice.”
“Pretreatment of cultures with diethyl maleate (DEM) or buthionine sulfoximine (BSO) increased the toxicity of allyl alcohol , precocene II and DC2P, but not SDS.”
Effects of culture duration, cytochrome P-450 inhibition and glutathione depletion on toxicity of diverse xenobiotics.“Although ethanol in itself did not induce DNA damage, a combination of BSO and ethanol increased the percentage by over 23% of that with BSO only.”
“The enhancing effects of ethanol in the presence of BSO are probably due to the induction of this isozyme in rat hepatocytes.”
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