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Last Updated: 3 years ago

Possible Interaction: Ethanol and Buthionine Sulfoximine

Research Papers that Mention the Interaction

Pretreatment of 100 mM ethanol treated VL-17A cells with 0.4 mM buthionine sulfoximine ( BSO ) or 1 mM diethyl maleate (DEM) had opposite effects.
Toxicology mechanisms and methods  •  2017  |  View Paper
The cytotoxicity of APAP or BSO to HLE/2E1 cells was inhibited by the addition of ethanol or vitamin E. However, the cytotoxicity of both APAP and BSO was enhanced by 24-h preincubation of HLE/2E1 cells with ethanol.
In Vitro Cellular & Developmental Biology - Animal  •  2007  |  View Paper
This effect was exacerbated in mice given ethanol with 7.6 mM BSO , causing a 72% decline in hepatic glutathione.
While ethanol alone caused no decrease in mitochondrial glutathione, inclusion of 7.6 mM BSO caused a 2-fold decline compared with untreated controls.
Alcoholism, clinical and experimental research  •  2007  |  View Paper
ET increased H(2)O(2) or O(2*-) only in the presence of BSO or DEM.
Alcoholism, clinical and experimental research  •  2006  |  View Paper
Combined treatment with BSO plus EtOH further decreased mitochondrial GSH up to 70% in comparison to control.
Biochemical pharmacology  •  1994  |  View Paper
The combined treatment of EtOH plus BSO induced a further mitochondrial GSH decrease up to 70% with respect to control.
Toxicology letters  •  1992  |  View Paper
The NMDA antagonists 2-amino-5-phosphonovaleric acid (APV), MK-801 and an inhibitor of glutamate synthesis, methionine sulfoximine , increased sensitivity to ethanol in both lines of mice.
Alcohol  •  1990  |  View Paper
Pretreatment of cultures with diethyl maleate (DEM) or buthionine sulfoximine (BSO) increased the toxicity of allyl alcohol , precocene II and DC2P, but not SDS.
Toxicology in vitro : an international journal published in association with BIBRA  •  1996  |  View Paper
Although ethanol in itself did not induce DNA damage, a combination of BSO and ethanol increased the percentage by over 23% of that with BSO only.
The enhancing effects of ethanol in the presence of BSO are probably due to the induction of this isozyme in rat hepatocytes.
International journal of oncology  •  1994  |  View Paper