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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“OBJECTIVE Previous research has suggested that both lithium and buspirone could lessen alcoholics' desire to drink as well as reduce the actual amounts of alcohol consumed.”
Pharmacological treatments for alcoholism: revisiting lithium and considering buspirone.“In animals, buspirone has been shown to alter drinking preference from alcohol to water.”
“The 5-HT1A receptor agonist buspirone is an anxiolytic which has been shown to diminish the desire to consume alcohol in anxious alcoholic patients.”
“ Buspirone offsets some of the impairment due to alcohol when the agents are combined.”
“Finally, we evaluated buspirone , an approved drug for anxiety disorders endowed with D3R antagonist activity (confirmed by molecular modeling analysis), that resulted effective in inhibiting ethanol intake.”
Dopamine D3 Receptor Is Necessary for Ethanol Consumption: An Approach with Buspirone“ Buspirone , a 5-HT1A agonist, has been shown to decrease the intake of ethanol when given as a single dose to rats with a psychological dependence induced according to our rat model of alcoholism.”
“On the first day, the buspirone injection decreased ethanol intake from the pretreatment value (1.94+/-0.18 g/kg/day), down to 1.36+/-0.18 g/kg (p < 0.01, n = 12).”
“Thus, an acute dose of buspirone can decrease voluntary ethanol intake in psychologically dependent rats, but long-lasting changes in the effect of buspirone seem to develop during a 3-week treatment period.”
“d-Fenfluramine, fluoxetine, buspirone , TFMPP, and DOI all produced a reduction in ethanol ingestion and maintained behaviour at doses that failed to reduce LMA.”
“In this situation, with a longer exposure to ethanol , a dose of 20 mg/kg of buspirone in week 90 reduced ethanol intake by approximately 40%, when compared with controls.”
“ Ethanol intake is significantly suppressed by zimelidine, bromocriptine, buspirone , and lithium carbonate, pharmacological agents that have been shown to be beneficial in controlling ethanol intake in alcohol-dependent humans.”
“The anxiogenic behaviour observed 12 h after ethanol withdrawal was inhibited by the 5-HT1A partial agonist, buspirone (200 micrograms/kg s.c.),”
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