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Last Updated: 4 months ago

Possible Interaction: Ethanol and Buspirone

supplement:

Ethanol

Research Papers that Mention the Interaction

Buspirone offsets some of the impairment due to alcohol when the agents are combined.
Pharmacotherapy  •  1984  |  View Paper
Buspirone , a 5-HT1A agonist, has been shown to decrease the intake of ethanol when given as a single dose to rats with a psychological dependence induced according to our rat model of alcoholism.
Thus, an acute dose of buspirone can decrease voluntary ethanol intake in psychologically dependent rats, but long-lasting changes in the effect of buspirone seem to develop during a 3-week treatment period.
Alcoholism, clinical and experimental research  •  1999  |  View Paper
d-Fenfluramine, fluoxetine, buspirone , TFMPP, and DOI all produced a reduction in ethanol ingestion and maintained behaviour at doses that failed to reduce LMA.
Alcohol  •  1998  |  View Paper
In this situation, with a longer exposure to ethanol , a dose of 20 mg/kg of buspirone in week 90 reduced ethanol intake by approximately 40%, when compared with controls.
Alcohol and alcoholism  •  1996  |  View Paper
In the present study on mice, the 5-HT1A receptor agonists (8-OH-DPAT), ipsapirone, and buspirone all antagonized the locomotor activity (LMA) stimulatory effect of ethanol (2.5 g/kg).
Alcohol  •  1994  |  View Paper
Ethanol intake is significantly suppressed by zimelidine, bromocriptine, buspirone , and lithium carbonate, pharmacological agents that have been shown to be beneficial in controlling ethanol intake in alcohol-dependent humans.
Proceedings of the National Academy of Sciences of the United States of America  •  1993  |  View Paper
The anxiogenic behaviour observed 12 h after ethanol withdrawal was inhibited by the 5-HT1A partial agonist, buspirone (200 micrograms/kg s.c.),
Alcohol and alcoholism (Oxford, Oxfordshire). Supplement  •  1993  |  View Paper
The anxiolytic-like activity of buspirone observed during ethanol withdrawal may be due to a reduction in serotonergic neurotransmission through activation of presynaptic 5-HT1A autoreceptors.
Alcohol  •  1991  |  View Paper
Ethanol and alprazolam appear to inhibit the excitability of bovine adrenal chromaffin cells by an action related to the former, while buspirone probably inhibits these cells through the latter.
Neuropharmacology  •  1991  |  View Paper
Although the saline control and 1.25 mg/kg dose of buspirone were without effect on alcohol intake, both the 5.0 and 20.0 mg/kg doses of buspirone attenuated significantly the consumption of alcohol by the monkeys.
Alcohol  •  1987  |  View Paper