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Last Updated: 4 months ago

Possible Interaction: Ethanol and Bupropion

supplement:

Ethanol

Research Papers that Mention the Interaction

Patients with a history of alcohol or chemical abuse were significantly less likely to respond to bupropion.
Journal of clinical psychopharmacology  •  2001  |  View Paper
Bupropion , 100 mg, had no effect alone but abolished the sedation and auditory vigilance impairment produced by alcohol when co-administered.
The Journal of clinical psychiatry  •  1983  |  View Paper
Combination of the top alcohol dose with bupropion , however, produced a significant reversal with lowered energy in the 4–7.5 Hz band.
Combination of bupropion with alcohol failed to change the blood alcohol concentration achieved.
British journal of clinical pharmacology  •  1982  |  View Paper
An expert report attributed the aggressive outburst to an interaction between bupropion and alcohol ; the accused was a social drinker and had never been violent.
The International journal of risk & safety in medicine  •  2011  |  View Paper
Acetonitrile, DMSO, and ethanol were shown to increase the Km and decrease the intrinsic clearance (CLint) of CYP2B6-mediated bupropion hydroxylation in a concentration-dependent manner.
Drug Metabolism and Disposition  •  2007  |  View Paper
Combination of the top alcohol dose with bupropion , however, produced a significant reversal with lowered energy in the 4–7.5 Hz band.
Combination of bupropion with alcohol failed to change the blood alcohol concentration achieved.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
A fatality due to the ingestion of bupropion and ethanol is presented.
Forensic science international  •  1992  |  View Paper
Pretreatment with ethanol produced a larger bupropion HCl-induced convulsive effect at all the doses (70% each at 100, 110 and 120 mg/kg) and a 10% effect in the ethanol + vehicle only group.
Annals of general psychiatry  •  2008  |  View Paper