Possible Interaction: Ethanol and Buprenorphine

“ Intravenous buprenorphine should be used cautiously in opioid users who, unlike the Iranian experience, mostly co-abuse benzodiazepines and/or ethanol [3].”

“Here, we report a case of death due to association of buprenorphine at therapeutic dose with benzodiazepines and ethanol.”

“Predictors of increased risk of use of diverted buprenorphine during the 6-month follow-up included inability to access buprenorphine treatment (AOR: 7.31, 95% CI: 2.07, 25.8), meeting criteria for generalized anxiety disorder, and past 30 day use of OxyContin, methamphetamine and/or alcohol.”

“Conversely, the patients injecting HDB used more illicit products, more benzodiazepines and more alcohol.”

“RESULTS Similar to prototypical micro-agonists, the two lowest doses of bu renorphine si gnificantly increased eth anol co nsumption (p < .01); in contrast, the two highest doses reduced it (p < .05).”

“At 1.5 h post-buprenorphine , all test doses greatly suppressed both EtOH and water intake at the 10-min interval.”

“ Buprenorphine produced a dose-dependent reduction in behavior maintained by PCP, ethanol or saccharin in all of the six groups.”

“ Buprenorphine reduced ethanol deliveries to about 50% at doses of 0.012 mg/kg and higher in group 5.”

“Pretreatment with an injection of 0.3 mg/kg buprenorphine significantly reduced ethanol self-injection in a group of 8 rats.”