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Last Updated: 2 months ago

Possible Interaction: Ethanol and Brotizolam

supplement:

Ethanol

Research Papers that Mention the Interaction

Coadministration of brotizolam with ethanol produces a small but significant impairment of brotizolam clearance.
brotizolam … ethanol , as opposed to the placebo cocktail, slightly imparied brotizolam clearance (1.85 vs 2.19 ml min-1 kg-1 P less than 0.… ml-1, P less than 0.05), and prolonged elimination half-life (5.2 vs 4.4 h, P less than 0.05).
British journal of clinical pharmacology  •  1986  |  View Paper
Brotizolam , nitrazepam and estazolam enhanced the sleeping time induced by ethanol and increased locomotor activity induced by methamphetamine, but did not affect the chewing behavior.
Arzneimittel-Forschung  •  1986  |  View Paper
In a second experiment the loss of righting reflexes induced by ethanol and hexobarbital was prolonged by brotizolam and diazepam depending on the dose.
Arzneimittel-Forschung  •  1986  |  View Paper