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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Brotizolam
Research Papers that Mention the Interaction
“Coadministration of brotizolam with ethanol produces a small but significant impairment of brotizolam clearance.”
“… brotizolam … ethanol , as opposed to the placebo cocktail, slightly imparied brotizolam clearance (1.85 vs 2.19 ml min-1 kg-1 P less than 0.… ml-1, P less than 0.05), and prolonged elimination half-life (5.2 vs 4.4 h, P less than 0.05).”
Kinetic and dynamic interaction of brotizolam and ethanol.“ Brotizolam , nitrazepam and estazolam enhanced the sleeping time induced by ethanol and increased locomotor activity induced by methamphetamine, but did not affect the chewing behavior.”
Effects of brotizolam on smooth muscle and other organs.“In a second experiment the loss of righting reflexes induced by ethanol and hexobarbital was prolonged by brotizolam and diazepam depending on the dose.”
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