Possible Interaction: Ethanol and Bromocriptine

“However, the long-acting dopamine agonist bromocriptine decreased ethanol intake and increased water intake producing a significant decrease in ethanol preference.”

“It has been established in experiments on rats subjected to long-term alcoholization that chronic administration of bromocryptin in small doses (1 mg/kg) considerably minimizes ethanol consumption by animals.”

“In contrast, bromocriptine (BRO; 1.0, 2.0 and 4.0 mg/kg) produced a significant, dose-dependent shift in preference from ethanol toward water by inhibiting responding for ethanol while enhancing water consumption.”

“L-NAME, BRM , QPR and 7-OH-DPAT blocked the ethanol (0.5 g/kg)-induced locomotor hyperactivity dose dependently and at doses that did not affect locomotor activity in naive mice when administered alone.”

“Coincident treatment with bromocriptine and ethanol reversed both of these effects with D1 receptors blocked.”

“Pretreatment with the … D2 agonist, bromocriptine (1–10 mg/kg) and the selective D3 agonists, 7-OH-DPAT (0.003–0.1 mg/kg), PD 128907 (0.….0001–0.003 mg/kg) and quinpirole (0.003–0.03 mg/kg), resulted in dose-dependent decreases in responding for ethanol.”

“These data suggest that BRO can potentiate ETOH intake and provide further support for the role of dopamine (DA) systems in mediating volitional oral intake of ETOH.”

“ Ethanol intake is significantly suppressed by zimelidine, bromocriptine , buspirone, and lithium carbonate, pharmacological agents that have been shown to be beneficial in controlling ethanol intake in alcohol-dependent humans.”

“Topical application of a dopamine agonist, bromocriptine , or L-beta-3,4-dihydroxyphenylalanine, significantly reduced the extent of damage induced by subsequent application of 70% ethanol.”

“Besides, bromocriptin decreases the rate of ethanol elimination from blood (3-fold in females, and 1.8-fold in males) and does not interfere with the reduction of ethanol concentration characteristic for the time of withdrawal.”