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Last Updated: 3 months ago

Possible Interaction: Ethanol and Bombesin

supplement:

Ethanol

Research Papers that Mention the Interaction

A number of peptides, including cholecystokinin (CCK), neurotensin, and bombesin , have been shown to interact with the CNS actions of alcohol and may play a role in alcohol withdrawal.
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism  •  1986  |  View Paper
The possibility of neuropeptide influence on ethanol intake is presented in light of new findings that cholecystokinin and bombesin inhibit ethanol consumption in the rat.
Neuroscience & Biobehavioral Reviews  •  1985  |  View Paper
Bombesin injection lowered the intake of ethanol , but not of water, in both phases of the lighting cycle and in both sexes.
Bombesin injection suppressed the intake of ethanol , but not of water, in rats with prior ethanol experience.
Bombesin is a bioactive tetradecapeptide found in nerves of the brain and gut and previously shown to inhibit intake of ethanol in forced-choice, one-bottle tests in water-deprived rats.
Alcohol  •  1992  |  View Paper
Of the other PLD activators tested, ethanol potentiated the PKC-dependent stimulatory effect of bombesin but failed to alter the apparently PKC-independent stimulatory effect of serum.
Biochimica et biophysica acta  •  1992  |  View Paper
Cholecystokinin (CCK) and bombesin (BBS) are neuropeptides of the brain and gut which have been shown to inhibit intake of ethanol.
Alcoholism, clinical and experimental research  •  1988  |  View Paper
Intracerebroventricular injection of bombesin more potently and completely inhibited the intake of ethanol but bombesin injected intraventricularly, unlike that given intraperitoneally, elicited excessive grooming and scratching behavior.
The intake of ethanol was less in rats with subdiaphragmatic vagotomies, but bombesin equivalently suppressed the intake.
This satiation effect to ethanol of peripherally administered bombesin appears to reflect a non-vagal, extra-ventricular neural action.
Neuropharmacology  •  1987  |  View Paper
Intraperitoneal injection of bombesin (4.0-16.0 micrograms/kg) or litorin (16.0 micrograms/kg) significantly inhibited ethanol intake.
Peptides  •  1985  |  View Paper
Abstract Intracisternal administration of three endogenous neuropeptides (neurotensin, β-endorphin, or bombesin ) potentiated the duration of sedation induced by a fixed dose of ethanol (5.2 g/kg) in mice.
Neuropharmacology  •  1981  |  View Paper
Ethanol (3.5 g/kg, IP) given simultaneously with neurotensin (30 micrograms, IC), bombesin (30 micrograms, IC) or beta-endorphin (20 micrograms, IC) caused a greater impairment of the reflex than ethanol alone.
Peptides  •  1981  |  View Paper