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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“A number of peptides, including cholecystokinin (CCK), neurotensin, and bombesin , have been shown to interact with the CNS actions of alcohol and may play a role in alcohol withdrawal.”
Clinical neuroendocrinology and neuropharmacology of alcohol withdrawal.“The possibility of neuropeptide influence on ethanol intake is presented in light of new findings that cholecystokinin and bombesin inhibit ethanol consumption in the rat.”
“ Bombesin injection lowered the intake of ethanol , but not of water, in both phases of the lighting cycle and in both sexes.”
“ Bombesin injection suppressed the intake of ethanol , but not of water, in rats with prior ethanol experience.”
“ Bombesin is a bioactive tetradecapeptide found in nerves of the brain and gut and previously shown to inhibit intake of ethanol in forced-choice, one-bottle tests in water-deprived rats.”
Bombesin reduces alcohol choice in nutritive expectancy and limited-access procedures.“Of the other PLD activators tested, ethanol potentiated the PKC-dependent stimulatory effect of bombesin but failed to alter the apparently PKC-independent stimulatory effect of serum.”
“Cholecystokinin (CCK) and bombesin (BBS) are neuropeptides of the brain and gut which have been shown to inhibit intake of ethanol.”
“Intracerebroventricular injection of bombesin more potently and completely inhibited the intake of ethanol but bombesin injected intraventricularly, unlike that given intraperitoneally, elicited excessive grooming and scratching behavior.”
“The intake of ethanol was less in rats with subdiaphragmatic vagotomies, but bombesin equivalently suppressed the intake.”
“This satiation effect to ethanol of peripherally administered bombesin appears to reflect a non-vagal, extra-ventricular neural action.”
“Intraperitoneal injection of bombesin (4.0-16.0 micrograms/kg) or litorin (16.0 micrograms/kg) significantly inhibited ethanol intake.”
“Abstract Intracisternal administration of three endogenous neuropeptides (neurotensin, β-endorphin, or bombesin ) potentiated the duration of sedation induced by a fixed dose of ethanol (5.2 g/kg) in mice.”
“ Ethanol (3.5 g/kg, IP) given simultaneously with neurotensin (30 micrograms, IC), bombesin (30 micrograms, IC) or beta-endorphin (20 micrograms, IC) caused a greater impairment of the reflex than ethanol alone.”
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