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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“A number of agents which interact with membranes or inhibit DNA repair, such as ethanol , lidocaine, verapamil and caffeine, have been reported to sensitize cells to bleomycin in vitro.”
Biochemical and cellular determinants of bleomycin cytotoxicity.“The hydroxy analog of WR‐1065, 2‐(3‐aminopropylamino) ethanol (WR‐OH), potentiates BLM only slightly, indicating the critical nature of the thiol group.”
“The cytotoxic effect of bleomycin on HeLa S3 cells is greatly enhanced when the cells are exposed to ethanol before drug treatment or treated with the drug at 43 degrees (hyperthermic temperature).”
“This effect of ethanol suggests a unique mode of action in sensitizing cells to bleomycin.”
“The antitumor effects of 41°C hyperthermia combined with bleomycin were enhanced by the additional use of ethanol , and these effects were more remarkable than those of 43°C hyperthermia and bleomycin.”
Enhanced antitumor effects of bleomycin and moderate hyperthermia by additional use of ethanol“However, posttreatment with ethanol potentiated the chromosome aberrations induced by ultraviolet light (UV), methyl methanesulfonate (MMS), mitomycin C (MMC) or bleomycin (BLM).”
“These results are discussed in terms of the ability of ethanol to inhibit cell recovery from potentially lethal damage after bleomycin treatment.”
“ Bleomycin cytotoxicity was also greatly potentiated by exposing the cells to ethanol at a concentration of more than 4% (v/v) at 37 degrees before or after drug treatment.”
“However, when the cells were exposed to ethanol during bleomycin treatment, the potentiation of cytotoxicity was reduced, and a higher concentration of ethanol was required for inducing equivalent sensitization.”
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