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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
drug:
Betulinic Acid
Research Papers that Mention the Interaction
“Administration of BA or BT significantly decreased CYP2E1 activities and expression of SREBP-1caused by ethanol , however, lower dosage of BA or BT showed slight effects on CYP2E1 activity or expression of SREBP-1c.”
“Administration of BA or BT significantly prevented the increases of serum ALT and AST caused by ethanol , as well as serum TG.”
Betulinic acid and betulin ameliorate acute ethanol-induced fatty liver via TLR4 and STAT3 in vivo and in vitro.“ BA pretreatment significantly reduced the serum levels of alanine transaminase, aspartate transaminase, total cholesterol, and triacylglycerides in a dose-dependent manner in the mice administered alcohol.”
Betulinic acid prevents alcohol-induced liver damage by improving the antioxidant system in mice“However, both betulin and betulinic acid inhibited the production of ROS by HSCs treated with ethanol and inhibited their migration as well as ethanol-induced TNF-α, and TGF-β1, production.”
“Fed‐batch cultivations with ethanol excess, using either an ethanol‐pulse feed or controlling a constant ethanol concentration in the fermentation medium, significantly enhanced production of betulinic acid and its triterpenoid precursors.”
Fermentation and purification strategies for the production of betulinic acid and its lupane‐type precursors in Saccharomyces cerevisiae
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