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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Ethanol
supplement:
Beta Carotene
Research Papers that Mention the Interaction
“By contrast, beta-carotene , a precursor of vitamin A, was considered innocuous until recently, when it was found to also interact with ethanol , which interferes with its conversion to retinol.”
“Furthermore, the combination of beta-carotene with ethanol results in hepatotoxicity.”
“Moreover, in smokers who also consume alcohol, beta-carotene supplementation promotes pulmonary cancer and, possibly, cardiovascular complications.”
“Thus ethanol , while promoting a deficiency of vitamin A also enhances its toxicity as well as that of beta-carotene.”
Alcohol, vitamin A, and beta-carotene: adverse interactions, including hepatotoxicity and carcinogenicity.“ Alcohol also alters the degradation of key nutrients, thereby promoting deficiencies as well as toxic interactions with vitamin A and beta carotene.”
“ Alcohol also alters the degradation of key nutrients, thereby promoting deficiencies as well as toxic interactions with vitamin A and beta-carotene.”
“In rats and baboons, the hepatotoxicity of chronic ethanol consumption is exacerbated by beta-carotene feeding , but the mechanism of this adverse effect is unknown.”
“ Beta-carotene plus alcohol accounted for 28.1% (95% CI = 16.8-39.4) of the cases.”
“Multiple linear regression analysis controlling for age, serum total cholesterol, serum triglycerides, … of green vegetables, yellow vegetables and fruit, showed that both smoking and alcohol had a … levels of beta‐carotene and alpha‐carotene; only smoking reduced the level of … alcohol significantly affected the level of lycopene or zeaxanthin.”
“These results suggest that plasma levels of beta-carotene among smokers and, perhaps, heavy consumers of alcohol may be reduced substantially below levels due to differences in diet.”
“In addition, ethanol consumption caused age-dependent decreases in the levels of GSH, selenium, vitamins, E, A and C, and beta-carotene and increases in the levels of oxidized glutathione (GSSG).”
Green tea supplementation in rats of different ages mitigates ethanol-induced changes in brain antioxidant abilities.“BACKGROUND Hepatotoxicity of ethanol is increased by beta-carotene in both rodents and nonhuman primates.”
“CONCLUSIONS Be a-carotene po tentiates the CYP2E1 induction by eth anol in rat liver and also increases CYP4A1, which may, at least in part, explain the associated hepatotoxicity.”
“ Ethanol seems to affect the homeostasis of beta-carotene.”
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