Possible Interaction: Ethanol and Berberine

“Alcohol consumption is a popular human social behavior worldwide, and the present study reports a comprehensive mechanism by which BBR protects against gastrointestinal injuries from alcohol stress , providing people with a novel application of BBR.”

“In conclusion, the present study demonstrates that treatment with berberine prevents the changes in oxidative stress and ChE activity, and consequently memory impairment in ethanol treated rats.”

“Furthermore, berberine also prevented the oxidative stress and macrosteatosis in response to chronic ethanol exposure in mice.”

“In conclusion, the results and evidence suggest that berberine exhibited an inhibitory influence against ethanol withdrawal‐induced hyperexcitability signs, which could be mediated through its neuromodulatory action.”

“ Berberine is also demonstrated to modulate the activity of several neurotransmitter systems like, dopamine, nitric oxide, serotonin, and NMDA, which are implicated in rewarding effects of ethanol.”

“In addition, berberine in these doses also reduced preference to ethanol drinking over water, but did not alter the general reward.”

“However, the expression of eNOS could be enhanced and iNOS expression could be inhibited by berberine (P<0.01).Conclusion Berberine could significantly protect gastric mucosa from damage by ethanol.”