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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Ethanol
drug:
Benzphetamine
Research Papers that Mention the Interaction
“ Chronic ethanol feeding similarly enhanced both microsomal cytochrome P-450 content and benzphetamine N-demethylase activity, per mg of protein, and resulted in a disproportionate increase in both aniline hydroxylase and 7-ethoxycoumarin O-deethylase activities.”
Differences in the duration of the enhancement of liver mixed-function oxidase activities in ethanol-fed rats after withdrawal.“In contrast, benzphetamine and benzo(a)pyrene oxidation rates were decreased 21-24% by ethanol.”
Induction and inhibition of cytochrome P-450-dependent monooxygenases in hamster tissues by ethanol.“The decrease seen for diazepam and d-benzphetamine N-demethylation caused by ethanol consumption was approximately 80% of control groups for the duration of the treatment.”
“Inhibition of benzphetamine N-demethylase activity occurred only at high concentrations of ethanol (100 mM) and was non-competitive in nature.”
“On the other hand, the activities of 7-ethoxycoumarin O-deethylase, benzphetamine N-demethylase and benzo[a]pyrene 3-hydroxylase were apparently decreased after ethanol treatment.”
“ Chronic ethanol treatment resulted in a significant induction of ethylmorphine and benzphetamine N-demethylase activity in both LS and SS mice with the SS selected line showing a greater (P < .05) maximal induction.”
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