Possible Interaction: Ethanol and Barbital

“In this respect ethanol and barbital are probably related.”

“ Barbital withdrawal signs were suppressed by pentobarbital, alcohol , chloroform, meprobamate, diazepam, chlordiazepoxide and oxazolam, but not by benzoctamine, perlapine or chlorpromazine.”

“However, cross-tolerance to barbital was observed after chronic treatment with ethanol.”

“ Barbital pretreatment also prevents the ethanol induced inhibition of glycerol utilization, and α-glycerophosphate accumulation in liver.”

“Brain levels of barbital , phenobarbital, acetaldehyde, and acetone were increased by ethanol.”

“Induction time was shortened and sleeping time lengthened by the administration of ethanol with each of the five barbiturates, the effects being most pronounced with barbital and phenobarbital.”

“The simultaneous administration of ethanol at doses of either 2, 3, or 4 g/kg intraperitoneally produced a dose-related decrease in the intraperitoneal LD50 for thiopentone, pentobarbitone, amylobarbitone, phenobarbitone and barbitone in rats.”

“The simultaneous administration of ethanol at doses of either 2, 3, or 4 g/kg intraperitoneally produced a dose‐related decrease in the intraperitoneal LD50 for thiopentone, pentobarbitone, amylobarbitone, phenobarbitone and barbitone in rats.”

“A study has also been made of the possible synergism between the action of barbitone and ethanol (on which conflicting reports have appeared (Gruber, 1955)) or 2-phenylethanol.”