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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Some studies have shown that ethanol ingestion may amplify the effect of aspirin and ibuprofen on human platelets and increase risk of bleeding [6–8].”
“The clinical risk for bleeding in patients taking aspirin or NSAIDs is enhanced by the concomitant use of ethanol.”
“The ingestion of aspirin before ethanol intake also increases the blood ethanol concentration by the inhibition of gastric alcohol dehydrogenase (ADH) [9].”
Fatty acid ethyl ester, a non‐oxidative ethanol metabolite, reverses the inhibitory effect of ibuprofen on platelet aggregation“There was no effect of ASA , ibuprofen or paracetamol on the single-dose kinetics of ethanol, but concurrent intake of ethanol reduced the peak concentration of ASA by 25%.”
“Conclusions: Intake of low-dose SA (75 mg daily) tends to delay the absorption of a moderate dose of e thanol, which results in lower peak blood-ethanol concentrations and smaller areas under the concentration–time curves.”
“The concentrations of paracetamol in plasma were lower when ethanol was ingested after treatment with ASA and the areas under the concentration–time curves (0–170 min) were smaller.”
“The highest HemoQuant levels were usually noted after concomitant administration of aspirin and ethanol at maximal doses for 3 days (P less than 0.005), some HemoQuant levels approaching 5 times the normal value.”
“It was found that 1) 20% ethanol does not damage the duodenal mucosa, whereas 40% ethanol does; 2) duodenal … lesions caused by 40% ethanol can be prevented by the previous administration of 20% ethanol; and 3) acetylsalicylic acid does not damage the duodenal … the protective effect of 20% ethanol. "”
“ Aspirin significantly increased faecal blood loss and this effect was significantly enhanced by the addition of alcohol.”
“ ASA , 600 mg 4 times daily, induced an increase in blood loss and this effect was significantly enhanced by the addition of alcohol.”
“The effects of aspirin and ethanol given together were additive and caused the greatest fall in potential difference.”
“Unbuffered aspirin and ethanol “broke” the barrier as shown by a rapid fall in potential difference.”
“Mean daily faecal blood loss associated with unbuffered aspirin ingestion was significantly increased by alcohol in the 13 subjects studied.”
“These findings suggest that alcohol may accentuate gastrointestinal blood loss associated with unbuffered aspirin ingestion.”
“In addition, alcohol has been found to have a synergistic effect with aspirin on bleeding times.”
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