Possible Interaction: Ethanol and Ascorbate

“These results indicate that ethanol stimulates the capacity to synthesize ascorbate which, in turn, causes an increase of ascorbic acid contents in the urine and soft tissues.”

“This is due to the participation of ascorbate in oxidoreducing processes connected with ethanol metabolism which leads to its irreversible destruction.”

“It was found that systemic application of ethanol induced brain ascorbate ( AA ) release.”

“The results suggest that ethanol-evoked release of AA probably is a self-protective mechanism against the neurotoxicity induced by ethanol in the brain, and the NMDA receptor may play an important role in this mechanism.”

“4-Methylpyrazole (50 mg/kg, IP), which inhibits alcoholdehydrogenase, could not prevent the increase in AA concentration, evoked by ethanol.”

“A single injection of ethanol , 1.0 g/kg intraperitoneally (IP), induced a significant increase in extracellular AA concentration in both the nucleus accumbens and striatum.”

“The ethanol load induces also a decrease in the cerebellar concentration of the three main endogenous anti-oxidant small molecules, i.e. alpha-tocopherol, ascorbate and glutathione.”

“Moderate concentrations of ethanol reduce the velocity of uptake of three representative Na+‐symport systems (D‐glucose, L‐alanine, L‐ascorbate ), whether electrogenic (the first two) or electroneutral (L‐ascorbate).”

“In the presence of copper, ethanol protected at [ascorbate] less than 1 mM, but was ineffective at [ ascorbate ] greater than 2 mM, even in the absence of oxygen.”

“ Ethanol treatment enhanced lipid peroxidation significantly, depletion in levels of hepatic glutathione and ascorbate , accompanied by a decline in the activities of glutathione peroxidase and glutathione reductase, and increased in hepatic glutathione s-transferase activity.”

“ Ethanol increases ascorbate retention.”